Publications (88)
ARTICLE
Untargeted Fecal Metabolomic Analyses across an Industrialization Gradient Reveal Shared Metabolites and Impact of Industrialization on Fecal Microbiome-Metabolome Interactions
Jacob J Haffner, Mitchelle Katemauswa, Thérèse S Kagone, Ekram Hossain, David Jacobson, Karina Flores , Adwaita R Parab, Alexandra J Obregon-Tito, Raul Y Tito, Luis Marin Reyes , Luzmila Troncoso-Corzo , Emilio Guija-Poma , Nicolas Meda , Hélène Carabin, Tanvi P Honap, Krithivasan Sankaranarayanan, Cecil M Lewis Jr , Laura-Isobel McCall
The metabolome is a central determinant of human phenotypes and includes the plethora of small molecules produced by host and microbiome or taken up from exogenous sources. However, studies of the metabolome have so far focused predominantly on urban, industrialized populations. Through an untargeted metabolomic analysis of 90 fecal samples fr(...)
human microbiome; industrialization; mass spectrometry; metabolomics
ARTICLE
Modelling factors associated with therapeutic inertia in hypertensive patients: Analysis using repeated data from a hospital registry in West Africa
Mahamadou Barro , Aristide Relwendé Yaméogo , Robert Darlin Mba , Rémi Kaboré , Germain Mandi , Désiré Lucien Dahourou , Patrice Zabsonré , Nicolas Méda , Juste Goungounga
The proportion of poorly controlled hypertensives still remains high in the general African population. This is largely due to therapeutic inertia (TI), defined as the failure to intensify or modify treatment in a patient with poorly controlled blood pressure (BP). The objective of this study was to identify the determinants of TI. We conducte(...)
: blood pressure variability, determinants, heterogeneity, hypertension
ARTICLE
Prevention of mother-to-child transmission of HIV at the second immunization visit: a cross-sectional study, Burkina Faso
Béninwendé Leticia Delphine Sakana , Anaïs Mennecier , Paulin Fao , Souleymane Tassembedo , Jean-Pierre Moles , Dramane Kania , Ajani Ousmane Taofiki , Franck Edgar Kadeba , Ibrahima Diallo , Sabrina Eymard-Duvernay , Morgana D'Ottavi , Nicolas Meda , Beatriz Mosqueira , Philippe Van de Perre , Nicolas Nagot
Objective To evaluate the performance of the cascade of activities for prevention of mother-to-child transmission (PMTCT) of human
immunodeficiency virus (HIV) at the second immunization visit in Burkina Faso.
Methods In a cross-sectional study, we recruited mothers attending the second immunization visit for their infant in 20 health centre(...)
Mots clés non renseignés
ARTICLE
Factors associated with mothers’ health care-seeking behaviours for childhood fever in Burkina Faso: fndings from repeated cross-sectional household surveys
Hermann Badolo, Aristide R. Bado, Hervé Hien, Nicolas Méda and A. Sathiya Susuman
Introduction: Fever is one of the most frequent reasons for paediatric consultations in Burkina Faso, but health careseeking behaviours and the factors associated with health care-seeking in the event of childhood fever are poorly
documented. This study aims to analyse the health care-seeking behaviours and the factors associated with health(...)
Childhood fever, Illness, Prevalence, Health care, Health care-seeking
ARTICLE
Investigation Around Cases of Crimean-Congo Hemorrhagic Fever-Mauritania, 2022
Boushab Mohamed Boushab,Pauline K. Yanogo,Djibril Barry, Hacen Ahmed Benane, Ahmed El Bara,Moussa Abdellah,Leonardo K. Basco and Nicolas Meda
Background
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent(...)
arbovirus
ARTICLE
Investigation Around Cases of Crimean-Congo Hemorrhagic Fever—Mauritania, 2022
Boushab Mohamed Boushab, Pauline K. Yanogo, Djibril Barry, Hacen Ahmed Benane, Ahmed El Bara, Moussa Abdellah, Leonardo K. Basco and Nicolas Meda
Background: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arbovirosis. Humans are infected by tick bites or contact with blood of infected animals. CCHF can be responsible for severe outbreaks due to human-to-human transmission. Our aims were to increase awareness and promote the search for risk factors and disease monitoring to prevent(...)
arbovirus, Crimean-Congo hemorrhagic fever, Mauritania
ARTICLE
Red blood cell alloimmunisation in multi-transfused patients from an haemodialysis service in Burkina Faso
Koumpingnin Nebie, Salam Sawadogo, Salifo Sawadogo, Jerome Koulidiati, Habi Y.A Lengani, Abdoul G. Sawadogo, Jerôme Babinet, Mohammed Khalloufi, Saliou Diop, Eleonore Kafando.
Background: In Burkina Faso, red blood cell (RBC) transfusion remains the crucial anaemia treatment following chronic renal failure (CRF) as erythropoietin and its analogues are unavailable. However, blood group matching beyond the ABO and Rhesus is not common in Burkina Faso. Thus, alloimmunisation is a potential issue for transfused patients(...)
blood transfusion, alloimmunisation, RBC antibody, CRF, Burkina Faso
ARTICLE
Epidemiological profile of measles in Niger: analysis of measles case-based surveillance data from 2010 to 2019
Habibatou Amadou Idé , Pauline Kiswendsida Yanogo , Djibril Barry , Ousmane Boua Togola , Eric Adehossi , Nicolas Meda
Measles is a rapidly growing disease in the world with 869,770 cases and 207,500 deaths recorded in 2019. Niger continues to record epidemic outbreaks despite the actions taken. This study aims to analyze the national database from 2010 to 2019 to characterize the epidemiology of measles in Niger. This is a descriptive retrospective study. Our(...)
Measles, Niger, database, surveillance
ARTICLE
Lactate dehydrogenase (LDH) and evaluation of response to breast cancer chemotherapy
Fabienne Marie SOUDRE, Alice KIBA, Arnaud KOURAOGO, Raoul KARFO, Aboubacar BAMBARA, Arsène KAGAMBEGA, Elie KABRE, Jean SAKANDE and Jacques SIMPORE
Breast cancer is the leading cause of cancer death in women worldwide. The aim of this study was to
determine the value of post-therapy serum LDH in assessing response at the completion of chemotherapy in
breast cancer patients. This was a prospective cross-sectional study with data collection from May 2019 to
November 2020, at the Unive(...)
Lactate dehydrogenase, LDH, breast cancer, chemotherapy, treatment response
ARTICLE
Long-Term Persistence of Mitochondrial DNA Instability in HIV-Exposed Uninfected Children during and after Exposure to Antiretroviral Drugs and HIV
Valérie Desquiret-Dumas 1 2, Morgana D'Ottavi 3, Audrey Monnin 3, David Goudenège 1 2, Nicolas Méda 4, Amélie Vizeneux 3, Chipepo Kankasa 5, Thorkild Tylleskar 6, Céline Bris 1 2, Vincent Procaccio 1 2, Nicolas Nagot 3, Philippe Van de Perre 3, Pascal Reynier 1 2, Jean-Pierre Molès 3
HIV-exposed uninfected (HEU) children show impaired health outcomes during childhood. A high rate of mitochondrial DNA (mtDNA) instability was reported in the blood of HEU at birth. We aimed to explore the relationship between these health outcomes and mtDNA deletions over time in a case series of 24 HEU children. MtDNA instability was assesse(...)
HIV, clinical outcomes, genetic alterations, mitochondria, neonates, neurodevelopment
ARTICLE
Long-Term Persistence of Mitochondrial DNA Instability in HIV-Exposed Uninfected Children during and after Exposure to Antiretroviral Drugs and HIV
Valérie Desquiret-Dumas 1 2, Morgana D'Ottavi 3, Audrey Monnin 3, David Goudenège 1 2, Nicolas Méda 4, Amélie Vizeneux 3, Chipepo Kankasa 5, Thorkild Tylleskar 6, Céline Bris 1 2, Vincent Procaccio 1 2, Nicolas Nagot 3, Philippe Van de Perre 3, Pascal Reynier 1 2, Jean-Pierre Molès 3
HIV-exposed uninfected (HEU) children show impaired health outcomes during childhood. A high rate of mitochondrial DNA (mtDNA) instability was reported in the blood of HEU at birth. We aimed to explore the relationship between these health outcomes and mtDNA deletions over time in a case series of 24 HEU children. MtDNA instability was assesse(...)
HIV, clinical outcomes, genetic alterations, mitochondria, neonates, neurodevelopment
ARTICLE
Screening for Hepatitis B in partners and children of women positive for surface antigen, Burkina Faso
Alice Nanelin Guingané 1, Rémi Kaboré 2, Yusuke Shimakawa 3, Eric Nagaonlé Somé 4, Dramane Kania 5, Amandine Pisoni 6, Nicolas Nagot 6, Rachel King 6, Roger Sombié 7, Nicolas Meda 5, Philippe Van de Perre 6, Edouard Tuaillon 6
Objective: To evaluate the implementation of a screening strategy for the partners and children of pregnant women with hepatitis B virus (HBV) attending antenatal care.
Methods: We identified pregnant women positive for HBV surface antigen (HBsAg) at antenatal consultation in Ouagadougou, Burkina Faso. At post-test counselling, women were a(...)
Mots clés non renseignés
ARTICLE
Screening for Hepatitis B in partners and children of women positive for surface antigen, Burkina Faso
Alice Nanelin Guingané 1, Rémi Kaboré 2, Yusuke Shimakawa 3, Eric Nagaonlé Somé 4, Dramane Kania 5, Amandine Pisoni 6, Nicolas Nagot 6, Rachel King 6, Roger Sombié 7, Nicolas Meda 5, Philippe Van de Perre 6, Edouard Tuaillon 6
Objective: To evaluate the implementation of a screening strategy for the partners and children of pregnant women with hepatitis B virus (HBV) attending antenatal care.
Methods: We identified pregnant women positive for HBV surface antigen (HBsAg) at antenatal consultation in Ouagadougou, Burkina Faso. At post-test counselling, women were a(...)
Mots clés non renseignés
ARTICLE
Contribution to the Valorization of Plants Used in the Management of Rheumatic Diseases in Burkina Faso
Aminata P. Nacoulma, Gontili Reine Elodie Karambiri, Naamwin-So-Bawfu Romaric Meda, Mindiédiba Jean Bangou, Moussa Ouedraogo, Dieu-Donné Ouedraogo
Joint pain is a real public health problem. According to recent studies, it is increasingly common in sub-Saharan Africa and represents a cause of greater loss of working days than accidents, heart disease and infections. The aim of this study was to study the pharmacochemical and therapeutic evidence of ten (10) plants used in the management(...)
Medicinal Plants, Anti-Inflammatory, Rheumatic Pathologies
ARTICLE
Knowledge, attitudes and practices of caregivers and laboratory agents on the pre-analytical phase of haematological analyses in Burkina Faso
Sawadogo Salam, Nebie Koumpingnin, Dondebzanga Barké Appolinaire, Nikiema/Miningou Myriam, Kima Donatien et Kafando Eleonore.
The pre-analytical phase of biological analyses is critical as it registers the most errors encountered within the testing process. This study aimed at assessing the knowledge, attitudes and practices of healthcare workers on the pre-analytical phase in haematological laboratory. A cross-sectional study using an auto-administered questionnaire(...)
Haematological analyses, laboratory request form, blood specimen sampling, Ouagadougou