ARTICLE
APOBEC3G expression and HIV-1 infection in Burkina Faso
- Journal of Public Health in Africa , 9 : 907-907
Lien de l'article :
https://doi.org/10.4081/jphia.2018.907
Discipline :
Sciences de la vie
Auteur(s) :
Tégwindé Rébeca Compaore, Serge Théophile Soubeïga, Abdoul Karim Ouattara, Daméhan Tchelougou, Cyrille Bisseyé, Didier Romuald Bakouan, Issaka Pierre Compaore, Augustine Dembele, Albert Théophane Yonli, Dorcas Obiri‐Yeboah, Florencia Wendkuuni Djigma, Jacques Simporè
Auteur(s) tagués :
OUATTARA Abdoul Karim
Renseignée par : OUATTARA Abdoul Karim
Résumé
APOBEC3G is a potent inhibitor of HIV-1 replication, and act by deaminating cytidines in uracil on the negative strand of the viral cDNA. In this case-control study, APOBEC3G expression in subjects’ naïve to HAART infected by HIV-1 and the effect of APOBEC3G polymorphism on its expression were evaluated. The results show that the HIV-1 infected carriers of the G minor alleles of the variant rs8177832 had a higher expression of APOBEC3G mRNA than the controls carriers of the G minor allele. APOBEC3G polymorphisms could play an important role in the modulation of the HIV-1 dissemination.
Mots-clés
APOBEC3G, HIV-1 infection, HIV-1 replication inhibition, cytidine deamination, Burkina Faso