This study aimed to evaluate the therapeutic potential of extracts from the leaves of Newbouldia laevis (P.
Beauv.) ex Bureau, a plant used in the management of diabetes. In this study, the different analyses focused on the anti-radical and anti-diabetic activities of selected extracts. Antidiabetic activity was studied by monitoring the inhibitory effect of the fractions on α-glucosidase, using the in vitro model. Anti-radical activities were evaluated by DPPH and ABTS methods. Ethyl acetate and butanol fractions showed better inhibitory effects against 𝛂-glucosidase enzymatic activity, with IC50 values estimated at 2.33 ± 0.13 μg/mL and 2.57 ± 0.18 μg/mL, respectively, compared to acarbose, whose IC50 is estimated at 0.57 ± 0.02 mg/mL. For free radical scavenging activity, the same fractions showed the highest DPPH● radical scavenging with IC50 values of 4.164 ± 0.085 and 11.454 ± 0.13 μg/mL, respectively. For the cationic ABTS●+ radical, the IC50 values are 2.61 ± 0.071 and 5.465 ± 0.022 μg/mL, respectively. These results suggest that Newbouldia laevis leaf extracts have significant anti-diabetic properties.

Newbouldia laevis, α-glucosidase, Antiradical, Anti-diabetic activity