Introduction: Waltheria indica Linn (Malvaceae) is a widely distributed plant in West Africa. It is commonly used in Burkina Faso to treat inflammation-related diseases, including asthma. Pre- vious reviews have focused on the ethnobotanical, traditional uses, phytochemistry, and phar- macological properties of Waltheria indica. This report aims to compile the biological and pharmacological activities that highlight the anti-asthmatic properties of Waltheria indica L. (W. indica).
Method: Electronic databases, such as PubMed, Scopus, Hinari, SciFinder, Google Scholar, and ScienceDirect, were used to gather data on Watheria indica. Data on the toxicological, anti- inflammatory, antioxidant, and bronchorelaxant effects of W. indica were collected.
Results: Twenty-three studies describing the biological and pharmacological activities relevant to assessing the anti-asthmatic properties of W. indica were found. Nine articles investigated the anti-inflammatory effects, and three manuscripts were found to have bronchorelaxant activity. Five publications reported the antioxidant activity of the plant extracts. Research on the extracts revealed a tolerable safety profile in rats and mice with an LD50 ranging from 300 to 5000 mg/kg body weight, depending on the parts of the plant used. Phenolic compounds, particularly flavo- noids, alkaloids, and saponins, were found to be responsible for the activities involved in the assessment of anti-asthmatic properties.
Conclusion: The results of this review suggest that W. indica could be a valuable resource for the treatment of asthma and other respiratory diseases. However, further chemical and pharmaco- logical investigations are needed to understand its mechanism of action in treating asthma.

Waltheria indica L., Anti-asthmatic properties, Toxicity, Phytochemistry, Asthma