Sickle cell disease is a real public health problem in the world
and particularly in Niger where the prevalence of the S gene is estimated at
25% and that of the homozygous forms at between 1% and 2%. Treatment
combines quarterly follow-up of patients and management of complications.
The objective of this study was to identify the potential explanatory factors of
non-adherence to treatment in sickle cell patients followed at the national reference
center for sickle cell disease in Niger. Methods: This is a cross-sectional
study of sickle cell cases followed at the CNRD in Niger. The population consisted
of all sickle cell patients followed in this center in 2021. The data collection
techniques were individual interviews and documentary reviews. Nonadherence
was assessed with the Girerd test. Descriptive statistical tests and
simple and multiple logistic regression models were performed. Results: A
total of 368 patients were enrolled. The median age is 7 years (4; 10) and the
sex ratio is 1.04. Ninety-eight (98) or 26.6% were compliant and 270 (73.4%)
were non-compliant. In multivariate analysis, the factors independently and
negatively associated with non-adherence to treatment were schooling (adjusted
OR [95% CI], p-value), 0.17 [0.10 - 0.30]; p

Associated Factors, Sickle Cell Disease, Non-Adherence to Treatment