Opioid free anesthesia (OFA) is a promising, new technique in anesthesia. The aim of this study is to evaluate the efficacy of an OFA protocol in maxillofacial surgery. This was a randomized, single-blind trial. 66 patients were recruited, with 33 in each group. Group 1 received OFA protocol and group 2 opioid protocol. The primary outcome measure was the highest pain score recorded, using a pain numerical scale (PNS), during the first two postoperative hours. Secondary outcome measures were the highest PNS score during the first 24 hours after surgery, the incidence of postoperative nausea and vomiting and the incidence of postoperative complications. The mean age in group 1 was 33.3±12.8 years and 31±12.6 years in group 2 (p = 0.58). The mean highest PNS score was 2.8±1.8 in group 1 and 4.1±1.6 in group 2 for the first two hours postoperatively (p = 0.001). It was 1.3±1.4 in group 1 and 3.2±1.8 in group 2 (p = 0.000) for the first 24 hours postoperatively. No postoperative complications were recorded in either group. OFA is a safe and effective anesthetic technique for patients undergoing maxillofacial surgery.