This study aims to estimate induced abortion incidence and safety in Burkina Faso using direct and indirect methods, overall and by women’s background characteristics. Data come from a nationally representative survey of reproductive aged women (n = 6,388). To address social desirability bias in abortion reporting, we asked about respondents’ closest female friends’ experience with abortion. The one-year abortion incidence in 2020 for respondents was 4.0 (95% CI 2.2–5.9) per 1,000 women aged 15–49 while the adjusted friend incidence was 22.9 (95% CI 15.8–30.0). Although not significant, abortion incidence was higher for adolescents, unmarried women, those with higher education, and those in urban areas among both respondents and their friends. Approximately nine out of ten abortions were unsafe (90% respondents, 95% friends), with respondent and friend findings suggesting higher risk of unsafe abortion among older women, less educated women, and women residing in rural areas. Despite recent increases in contraceptive use and continued legal restrictions, abortion remains common in Burkina Faso and is largely unsafe, with evidence of potential disparities.