Introduction: Ameloblastoma is a benign odontogenic tumor with a controversial prognosis due to its potentially
aggressive and recurrent evolution. We report a case of brain invasion by a multi-recurrent angulo-mandibular
ameloblastoma.
Objective: Report the therapeutic difficulties and evolutive surprises of multi-recurrent ameloblastoma through
the study of a case of cerebral invasion and a review of the literature.
Observation: K. S., a 34-year-old female patient was seen in consultation in 2009 for a histologically confirmed
ameloblastoma of the right mandibular angle. Operated four times after three recurrences, the patient was seen
11 years after the first diagnosis, in a pattern of intracranial hypertension syndrome and CT scan revealed a
homolateral endocranial expansive process. Operated in neurosurgery in 2020, the patient died in the postoperative
period. The histology of the surgical specimen obtained confirmed the diagnosis of plexiform
ameloblastoma.
Conclusion: The benignity of multi-recurrent ameloblastoma must be nuanced. A radical surgical treatment does
not exclude recurrences and secondary localizations.

Multi-recurrent ameloblastoma, Brain invasion, Odontogenic benign tumor