Objective: Rheumatoid arthritis is a chronic inflammation of the joints that leads to severe bone destruction. Plants can help relieve these diseases. The aim of this study was to evaluate the anti-arthritic effect of aqueous extract of Sarcocephalus latifolius fruit on chronic Freund's adjuvant-induced arthritis in rats. Materials and Methods: Five groups of rats were injected with 0.1 ml of CFA. These different groups were orally treated with distilled water at 1 ml/kg, Sarcocephalus latifolius extract at 100, 250 and 500 mg/kg and prednisone (5 mg/kg) for 21 days. Normal rats served as controls. Inflammation diameter, hematological and biochemical analyses, tissue oxidative markers and paw histological sections were evaluated. Results: On day 21, the 500 mg/kg extract produced a 48 % inhibition compared with control rats. This effect was the maximum inhibition. Aqueous extract of Sarcocephalus latifolius, at doses of 250 and 500 mg/kg, significantly (p

Sarcocephalus latifolius, rats, Anti-arthritis, complete Freund’s adjuvant