Water quality indices are important tools for ecosystem health assessment and potential water security indicators, but still missing in Togo. To fill this gap, biological and water quality indices performance in a basin of Lake Togo watershed were investigated. Fifty sampling sites were selected in three sections of rivers/streams (upstream, middle stream, downstream) through the basin. To test performance of biological and chemical water quality indices in Lake Togo context, one biotic index, Family Biotic Index (FBI), two metrics (number of taxa in the insects’ order of Ephemeroptera, Plecoptera and Trichoptera (EPT), number of taxa in the insects’ order of Ephemeroptera, Trichoptera and Odonata (ETO), and one chemical water quality index, Prati’s Index (WQI) were used. The biotic index and metrics were calculated using macroinvertebrates features (number of taxon, diversity index and abundance) of Zio River basin. The chemical-based water quality index was derived from measurements of water physicochemical parameters. The result showed that all biological indices were sensitive to a set of organic pollution and bacteriological indicators, which correspond to a set of human pressures affecting the ecological integrity of all basin waterbodies (r 0.60; p

water quality, indices, West Africa, water management, aquatic ecosystem, pollution