Host factors such as APOBEC3G were associated with hypermutation, which might interfere with HBV replication. Te need to assess the impact of APOBEC3G polymorphisms on a hepatitis B-infected population is highlighted by a previous study. Tus, our study aimed to characterize two APOBEC3G single nucleotide polymorphisms and evaluate their association among chronic carriers of hepatitis B in Burkina Faso. Tree hundred forty-fve (345) individuals were recruited, including 106 HBsAg positive and 239 HBsAg negative. APOBEC3G polymorphisms rs6001417 and rs8177832 DNA genotyping were characterized by TaqMan allelic discrimination. Te minor allele G of rs600417 frequency was higher among participants with chronic hepatitis B. Furthermore, rs600417 was associated with the dominant model (p