High blood pressure (HBP) is the first risk factor for death in the world according to the World Health Organization (WHO). Several plant-based formula including Jatropha curcas leaves are proposed. This study aim at evaluating its hypotensive and antioxidant effects and to investigate the different chemical groups. In the study of hypotensive effects the invasive method was used. The DPPH method was used for the evaluation of antioxidant effects. JCLAE in cumulative doses decreased the mean arterial pressure of normotensive rats in a dose-dependent manner with a maximum effect of 69.12%. Administration of atropine prior to JCLAE resulted in a decrease in hypotension caused by the extract alone. The phytochemical study revealed the presence of Flavonoids, Tannins, Saponins and Terpenoids/steroids. Also, an antioxidant activity of 67.597 ± 1.833 was determined. The presence of all these chemical compounds could be at the origin of the hypotensive effects recorded. The study showed that JCLAE has a hypotensive property. This property justifies its use in traditional medicine as a hypotensive.

Jatropha curcas, Hypotensive, antioxidant, phytochemical contents