Background : Excoecaria grahamii is a traditional medicinal plant use in Burkina Faso and other part in the word to treat many diseases. However, its antioxydant and antidiabetic effects are not yet demonstrated. Objective : The aim of this study was to investigate the potential inhibitory effects of aqueous and ethanolic extracts of leaves and roots of Excoecaria grahamii on oxidative stress and hyperglycemia. Materials and Method : The antioxidant effect was investigated by FRAP, DPPH and ABTS essays while the anti-hyperglycemic effect were evaluated using α-amylaseand β-galactosidase inhibitory assays. In addition, the phytochemical screening for some targeted compounds wascarried out. Results : The result has shown that Excoecaria grahamii have antioxidant effect. Regarding the antidiabetic effect our data have shown only an inhibitory effect on α-amylase enzyme but not on β-galactosidase. Phytochemical study has shown the presence of gallic tannins, terpenoids and flavonoids in all the extract. Only aqueous extract have shown saponins. No catechic tannins and anthraquinones have been showed. Conclusions : This study suggests that Excoecaria grahamii contain chemicals components that can reduce oxidative stress and post prandial glucose enhance. It can be useful in the fight against antioxidant-related diseases such as those seen during ageing.

Excoecaria grahamii, antioxidant, anti-hyperglycemia, α-amylase