Objectives A cluster of specialized KIR genes of specialized KIR genes has been
shown to be associated with susceptibility or resistance to viral infections in
humans. Therefore, this pilot study, this pilot investigation sought to
determine the frequencies of KIR genes human immunodeficiency virus type 1(
HIV-1) patients and establish their potential clinical involvement in disease
progression and staging. Methods HIV-1 infected and healthy individuals were
selected for this study. Hepatitis B surface antigen (HBsAg), anti-HCV
antibodies and anti-HIV-1/2 antibody/ antigen were screened using a 4th
generation ELISA assay (Cobas e 411 Analyzer, Roche Diagnostics GmbH Mannheim,
Germany). SSP-PCR was used to evaluate the frequencies of KIR genes. CD4+ T
counts and HIV-1 viral load were measured in patients using respectively BD
FACSCount and Abbott m2000rt instruments. Results We found a significant
association between the frequencies of KIR2DL2 (OR=4.41; p

Burkina Faso; HIV-1; KIR gene; T CD4; Viral Load.