BACKGROUND: Prostate cancer (Pca) is a public health problem that affects men,
usually of middle age or older. It is the second most common cancer diagnosed in
men and the fifth leading cause of death. The RNASEL gene located in 1q25 and
identified as a susceptibility gene to hereditary prostate cancer, has never
been studied in relation to prostate cancer in Burkina Faso. The aim of this
study was to analyze the carriage of RNASEL R462Q and D541E mutations and risks
factors in patients with prostate cancer in the Burkina Faso.
METHODS: This case-control study included of 38 histologically diagnosed
prostate cancer cases and 53 controls (cases without prostate abnormalities).
Real-time PCR genotyping of R462Q and D541E variants using the TaqMan® allelic
discrimination technique was used. Correlations between different genotypes and
combined genotypes were investigated.
RESULTS: The R462Q variant was present in 5.3% of cases and 7.5% of controls.
The D541E variant was present in 50.0% of cases and 35% of controls. There is no
association between R462Q variants (OR = 0.60; 95%IC, 0.10-3.51; p = 0.686) and
D541E variants (OR = 2.46; 95%IC, 0.78-7.80; p = 0.121) and genotypes combined
with prostate cancer. However, there is a statistically significant difference
in the distribution of cases according to the PSA rate at diagnosis (p ˂ 0.001).
For the Gleason score distribution, only 13.2% of cases have a Gleason score
greater than 7. There is a statistically significant difference in the Gleason
score distribution of cases (p ˂ 0.001).
CONCLUSIONS: These variants, considered in isolation or in combination, are not
associated with the risk of prostate cancer.

Burkina Faso; D541E; Prostate cancer; R462Q; RNASEL.