Hemoglobinopathies, mainly Sickle cell disease (SCD), are the most common
monogenic disorders in Africa. In Burkina Faso, data on these diseases are
scarce, mainly hospital-based in Ouagadougou and its surroundings. In order
to assess the incidence and allelic frequencies of the main hemoglobinopathies
in newborns in Burkina Faso, we conducted a cross-sectional study from 2015
to 2019 in four hospitals. The study included babies of both sexes, regardless of
ethnic group and parents’ hemoglobin status. It was a newborn screening and
hemoglobin variants were detected using isoelectric focusing on cord blood
samples and confirmed using hemoglobin electrophoresis by high-performance
liquid chromatography. The proportions and cumulative incidences of the different
hemoglobinopathies were computed. Hardy-Weinberg equilibrium law
was applied to calculate genotypic and allelic frequencies. The significant level
was p