Introduction: The risk of transmission of pathogens such as hepatitis B virus
threatens the safety of transfused patients especially in high endemic areas.
The aim of this study was to determine the incidence and factors associated
with hepatitis B virus surface antigen (HBsAg) seroconversion in blood donors
at the Regional Blood Transfusion Centre of Ouagadougou. Methods: A
retrospective cohort study of voluntary non-remunerated blood donors
(VNRBD), was conducted from 2008 to 2017. Data on HBsAg seroconversion
were collected. The Kaplan-Meier method and the Log-Rank test were used to
estimate the survival curves. Cox’s regression identified the factors associated
with this seroconversion. Results: Of 23,494 donors, 559 had HBsAg seroconversion.
The number of donor years was 58,637.50 and the HBV incidence
rate was 9.53 per 1000 donor years. The median seroconversion time
was 75.73 months with extremes of 2.7 months and 107.12 months. The risk
of seroconversion was 1.30 times higher among donors aged 21 to 24 years
old (p = 0.007) and 2.49 times higher among those over 24 years old (p

Time to Onset, Viral Hepatitis B, Blood Donors