The emergence of bacterial resistance to antibiotics is a serious challenge to the global health system. The QS inhibition is one of the approaches to fight against antibiotic resistance in bacteria. Securidaca longepedunculata is a medicinal plant that roots are the only organ used against microbial diseases. This species is threatened with extinction due to the massive use of its roots in phytotherapy. In this study, the anti-QS and anti-biofilm activities of S. longepedunculata leaves methanolic extract at 100 to 400 µg/mL was assessed against the bacterial strains Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PAO1. The results showed anti-QS and anti-biofilm activity of S. longepedunculata leaves which reduced violacein production in C. violaceum CV026 by 12 to 59%. The virulence factor pyocyanin in P. aeruginosa PAO1 was inhibited from 13 to 46%. Biofilm formation was
significantly inhibited (41%) at 400 µg/mL.

Securidaca longepedunculata, anti-quorum, anti-biofilm