Studying some neuroprotective effects of Calotropis procera extracts against scopolamine- induced neuropschiatric comorbidities in a rodent model of epilepsy.

---

Résumé

Many plants are largely used in alternative medicine of Burkina Faso for neuropsychiatric disorders treatment.
However, their neuro-pharmacological properties are less evaluated through scientific studies. The present study
aims to evaluate the neuroprotective effect of Calotropis procera leaves and root-bark aqueous extract, focusing on
a scopolamine-inducedmodel of epilepsy in rodents. In this study, we evaluated this plant extracts possible protective
effects on the central nervous system, through the behavioral tests and the enzymes activity assays. Thus, elevated
plus-maze test andY-maze taskwere used to evaluate animals behavioral andUV/visible spectrophotometermethods
were used to evaluate the enzyme’s activities in brain’s supernatant.

Mots-clés

Calotropis procera, anti-amnesic, antioxidant, behavioral; neuroprotective